期刊论文详细信息
Clinical Epigenetics | |
Association of immune cell composition with the risk factors and incidence of acute coronary syndrome | |
Research | |
Yu Yan1  Chaolong Wang1  Minghui Jiang1  Lin Ding1  Shanshan Cheng1  Minghan Qu1  Yi Jiang1  Xingjie Hao1  Ziwei Zhu1  Chengguqiu Dai1  Xian Shi1  Xiaomin Zhang2  | |
[1]Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | |
[2]Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | |
关键词: Acute coronary syndrome; Immune cell composition; Risk factor; DNA methylation; | |
DOI : 10.1186/s13148-023-01527-4 | |
received in 2022-12-16, accepted in 2023-06-28, 发布年份 2023 | |
来源: Springer | |
【 摘 要 】
BackgroundAlthough immune cells are involved in acute coronary syndrome (ACS), few studies have explored the association of incident ACS with the relative immune cell proportions. We aimed to investigate the association of immune cell proportions with the incidence and risk factors of ACS in the Dongfeng–Tongji cohort.MethodsWe conducted the analyses with 38,295 subjects from the first follow-up of the Dongfeng–Tongji cohort, including DNA methylation profiles for 1570 individuals. The proportions of immune cell types were observed from routine blood tests or estimated from DNA methylation profiles. For both observed and estimated immune cell proportions, we tested their associations with risk factors of ACS by multivariable linear regression models. In addition, the association of each immune cell proportion with incident ACS was assessed by the Cox regression model and conditional logistic regression model, respectively, adjusting for the risk factors of ACS.FindingsThe proportions of lymphocytes, monocytes, and neutrophils showed strong associations with sex, followed by diabetes. Moreover, sex and current smoking were the two factors with strongest association with the proportions of lymphocyte subtypes. The hazard ratio (HR) and 95% confidence interval (CI) of incident ACS per standard deviation (SD) increase in proportions of lymphocytes and neutrophils were 0.91 (0.85–0.96) and 1.10 (1.03–1.16), respectively. Furthermore, the OR (95% CI) of incident ACS per SD increase in proportions of NK cells, CD4+ T cells, and B cells were 0.88 (0.78–0.99), 1.15 (1.03–1.30), and 1.13 (1.00–1.26), respectively.InterpretationThe proportions of immune cells were associated with several risk factors of ACS, including sex, diabetes, and current smoking. In addition, proportion of neutrophils had a risk effect, while proportion of lymphocytes had a protective effect on the incidence of ACS. The protective effect of lymphocytes was probably driven by NK cells.【 授权许可】
CC BY
© The Author(s) 2023
【 预 览 】
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