Animal models of Parkinson’s disease: bridging the gap between disease hallmarks and research questions

Translational Neurodegeneration

Review

Cyril Bolduc¹  Modesto R. Peralta III¹  Victoria Soto Linan¹  Charles Gora¹  Axelle Dovonou¹  Martin Lévesque² 

[1] CERVO Brain Research Centre, 2601, Chemin de la Canardière, G1J 2G3, Québec, QC, Canada;CERVO Brain Research Centre, 2601, Chemin de la Canardière, G1J 2G3, Québec, QC, Canada;Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada;

关键词: Parkinson’s disease;    Animal model;    Alpha-synuclein;    Transgenic model;    Preformed fibril;    Mouse;   

DOI  :  10.1186/s40035-023-00368-8

 received in 2023-03-13, accepted in 2023-06-19,  发布年份 2023

来源: Springer

【 摘 要 】

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. More than 200 years after its first clinical description, PD remains a serious affliction that affects a growing proportion of the population. Prevailing treatments only alleviate symptoms; there is still neither a cure that targets the neurodegenerative processes nor therapies that modify the course of the disease. Over the past decades, several animal models have been developed to study PD. Although no model precisely recapitulates the pathology, they still provide valuable information that contributes to our understanding of the disease and the limitations of our treatment options. This review comprehensively summarizes the different animal models available for Parkinson’s research, with a focus on those induced by drugs, neurotoxins, pesticides, genetic alterations, α-synuclein inoculation, and viral vector injections. We highlight their characteristics and ability to reproduce PD-like phenotypes. It is essential to realize that the strengths and weaknesses of each model and the induction technique at our disposal are determined by the research question being asked. Our review, therefore, seeks to better aid researchers by ensuring a concrete discernment of classical and novel animal models in PD research.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 6