Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes

Journal of Neuroinflammation

Review

Xiangru Wang¹  Ruicheng Yang¹  Huanchun Chen¹  Chen Tan¹  Wei Liu²  Bo Yang³ 

[1]National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, 430070, Wuhan, China

[2]Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, 430070, Wuhan, China

[3]Frontiers Science Center for Animal Breeding and Sustainable Production, 430070, Wuhan, China

[4]National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, 430070, Wuhan, China

[5]Wuhan Academy of Agricultural Sciences, 430070, Wuhan, China

[6]National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, 430070, Wuhan, China

[7]Wuhan Keqian Biological Co., Ltd., 430070, Wuhan, China

关键词: Neuroinflammation;    miRNAs;    lncRNAs;    circRNAs;    Microglia;    Astrocytes;   

DOI  :  10.1186/s12974-023-02856-0

 received in 2023-06-02, accepted in 2023-07-18,  发布年份 2023

来源: Springer

【 摘 要 】

Neuroinflammation has been implicated in the initiation and progression of several central nervous system (CNS) disorders, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, ischemic stroke, traumatic brain injury, spinal cord injury, viral encephalitis, and bacterial encephalitis. Microglia and astrocytes are essential in neural development, maintenance of synaptic connections, and homeostasis in a healthy brain. The activation of astrocytes and microglia is a defense mechanism of the brain against damaged tissues and harmful pathogens. However, their activation triggers neuroinflammation, which can exacerbate or induce CNS injury. Non-coding RNAs (ncRNAs) are functional RNA molecules that lack coding capabilities but can actively regulate mRNA expression and function through various mechanisms. ncRNAs are highly expressed in astrocytes and microglia and are potential mediators of neuroinflammation. We reviewed the recent research progress on the role of miRNAs, lncRNAs, and circRNAs in regulating neuroinflammation in various CNS diseases. Understanding how these ncRNAs affect neuroinflammation will provide important therapeutic insights for preventing and managing CNS dysfunction.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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