Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical Management

Frontiers in Endocrinology

卷:12

Mina Wang¹  Zehuan Liao²  Tiange Chi⁴  Jiaran Lin⁵  Yihan Zhao⁵  Peng Wei⁷ 

[1] Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, China;

[2] Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden;

[3] Department of Nephrology and Endocrinology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China;

[4] First Clinical Medical College, Beijing University of Chinese Medicine, Beijing, China;

[5] Graduate School, Beijing University of Chinese Medicine, Beijing, China;

[6] School of Biological Sciences, Nanyang Technological University, Singapore, Singapore;

[7] School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China;

关键词: ncRNAs;    miRNAs;    lncRNAs;    circRNAs;    diabetes;    biomarker;   

DOI  :  10.3389/fendo.2021.630032

来源: DOAJ

【 摘 要 】

Diabetes, a metabolic disease characterized by high blood glucose and other complications, has undefined causes and multiple risk factors, including inappropriate diet, unhealthy lifestyles, and genetic predisposition. The two most distinguished types of diabetes are type 1 and type 2 diabetes, resulting from the autoimmune impairment of insulin-generating pancreatic β cells and insulin insensitivity, respectively. Non-coding RNAs (ncRNAs), a cohort of RNAs with little transcriptional value, have been found to exert substantial importance in epigenetic and posttranscriptional modulation of gene expression such as messenger RNA (mRNA) silencing. This review mainly focuses on the pathology of type 2 diabetes (T2D) and ncRNAs as potential biomarkers in T2D development and clinical management. We consolidate the pathogenesis, diagnosis, and current treatments of T2D, and present the existing evidence on changes in multiple types of ncRNAs in response to various pathological changes and dysfunctions in different stages of T2D.

【 授权许可】

Unknown