Italian Journal of Pediatrics | |
Clinical value of combined serum CA125, NSE and 24-hour urine VMA for the prediction of recurrence in children with neuroblastoma | |
Research | |
Mo Chen1  Jinmin Li2  Zilong Qi2  Xiangyang Liu2  Jiachen Wang2  | |
[1] Disinfection & Supply Department, Cangzhou Central Hospital, No. 16 Xinhua West Road, 061000, Cangzhou, Hebei, China;Pediatric Surgery Department, Cangzhou Central Hospital, Children’s Hospital District, Intersection of Guangrong Road, Fuyang South Avenue, 061000, Cangzhou, Hebei, China; | |
关键词: Neuroblastoma; CA125; NSE; VMA; Children; | |
DOI : 10.1186/s13052-023-01508-6 | |
received in 2023-04-23, accepted in 2023-08-09, 发布年份 2023 | |
来源: Springer | |
【 摘 要 】
BackgroundIn this study, we intend to retrospectively analyze the clinical data of postoperative neuroblastoma children, including the results of follow-up examinations and laboratory tests, to explore the clinical value of combined serum Carbohydrate antigen 125 (CA125), neuron-specific enolase (NSE) and 24-hour urine vanillylmandelic acid (VMA) levels at baseline for the prediction of recurrence in children with neuroblastoma.Methods265 children with neuroblastoma were successfully followed up, including 163 cases without recurrence (non-recurrence group) and 102 cases with recurrence (recurrence group). The levels of 24-hour urine VMA were determined using spectrophotometric methods. Additionally, the serum levels of CA125 and NSE were measured using electrochemiluminescence immunoassay.ResultsThe serum CA125, NSE and 24-hour urine VMA levels were significantly higher in the recurrence group than in the non-recurrence group. It demonstrated a significant positive correlation between the levels of serum CA125, NSE, and 24-hour urine VMA in all children with neuroblastoma. All children in stage IV of neuroblastoma had the highest level of serum CA125, NSE and 24-hour urine VMA and vice versa. The combined CA125, NSE and VMA had significantly better sensitivity and specificity than an individual marker.ConclusionsCombined serum CA125, NSE and 24-hour urine VMA had the potential to predict neuroblastoma recurrence more effectively.
【 授权许可】
CC BY
© Società Italiana di Pediatria 2023
【 预 览 】
Files | Size | Format | View |
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RO202309154980309ZK.pdf | 1202KB | download | |
Fig. 1 | 396KB | Image | download |
42490_2023_74_Article_IEq35.gif | 1KB | Image | download |
Fig. 3 | 377KB | Image | download |
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Fig. 3
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Fig. 1
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]
- [31]
- [32]
- [33]
- [34]
- [35]
- [36]
- [37]