Clinical value of combined serum CA125, NSE and 24-hour urine VMA for the prediction of recurrence in children with neuroblastoma

Italian Journal of Pediatrics

Research

Mo Chen¹  Jinmin Li²  Zilong Qi²  Xiangyang Liu²  Jiachen Wang² 

[1] Disinfection & Supply Department, Cangzhou Central Hospital, No. 16 Xinhua West Road, 061000, Cangzhou, Hebei, China;Pediatric Surgery Department, Cangzhou Central Hospital, Children’s Hospital District, Intersection of Guangrong Road, Fuyang South Avenue, 061000, Cangzhou, Hebei, China;

关键词: Neuroblastoma;    CA125;    NSE;    VMA;    Children;   

DOI  :  10.1186/s13052-023-01508-6

 received in 2023-04-23, accepted in 2023-08-09,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundIn this study, we intend to retrospectively analyze the clinical data of postoperative neuroblastoma children, including the results of follow-up examinations and laboratory tests, to explore the clinical value of combined serum Carbohydrate antigen 125 (CA125), neuron-specific enolase (NSE) and 24-hour urine vanillylmandelic acid (VMA) levels at baseline for the prediction of recurrence in children with neuroblastoma.Methods265 children with neuroblastoma were successfully followed up, including 163 cases without recurrence (non-recurrence group) and 102 cases with recurrence (recurrence group). The levels of 24-hour urine VMA were determined using spectrophotometric methods. Additionally, the serum levels of CA125 and NSE were measured using electrochemiluminescence immunoassay.ResultsThe serum CA125, NSE and 24-hour urine VMA levels were significantly higher in the recurrence group than in the non-recurrence group. It demonstrated a significant positive correlation between the levels of serum CA125, NSE, and 24-hour urine VMA in all children with neuroblastoma. All children in stage IV of neuroblastoma had the highest level of serum CA125, NSE and 24-hour urine VMA and vice versa. The combined CA125, NSE and VMA had significantly better sensitivity and specificity than an individual marker.ConclusionsCombined serum CA125, NSE and 24-hour urine VMA had the potential to predict neuroblastoma recurrence more effectively.

【 授权许可】

CC BY   
© Società Italiana di Pediatria 2023

【 图 表 】

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