The MARS PETCARE BIOBANK protocol: establishing a longitudinal study of health and disease in dogs and cats

BMC Veterinary Research

Study Protocol

Colby Woodruff¹  JoAnn Morrison²  Teresa Lightfoot³  Brenda Fulcher³  Philip J. Bergman⁴  Tracy Mills⁴  Talon S. McKee⁴  Richard Haydock⁵  Laura Carvell-Miller⁵  Phillip Watson⁵  Claire E. Bowring⁵  Serina Filler⁵  Janet E. Alexander⁵  Darren W. Logan⁵ 

[1] Antech Diagnostics, 17620 Mount Herrmann St, Fountain Valley, CA, USA;Banfield Pet Hospital, 18101 SE 6Th Way, Vancouver, WA, USA;BluePearl Science, 2950 Busch Lake Blvd, Tampa, FL, USA;VCA Clinical Studies, 12401 West Olympic Blvd, Los Angeles, CA, USA;Waltham Petcare Science Institute, Waltham On the Wolds, Leicestershire, UK;

关键词: Repository;    Feline;    Canine;    Risk factors;    Prospective;    Cohort;    Longitudinal;    Disease;    Genomic;    Microbiome;    Biomarker;   

DOI  :  10.1186/s12917-023-03691-4

 received in 2022-10-21, accepted in 2023-08-09,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe veterinary care of cats and dogs is increasingly embracing innovations first applied to human health, including an increased emphasis on preventative care and precision medicine. Large scale human population biobanks have advanced research in these areas; however, few have been established in veterinary medicine. The MARS PETCARE BIOBANK™ (MPB) is a prospective study that aims to build a longitudinal bank of biological samples, with paired medical and lifestyle data, from 20,000 initially healthy cats and dogs (10,000 / species), recruited through veterinary hospitals over a ten-year period. Here, we describe the MPB protocol and discuss its potential as a platform to increase understanding of why and how diseases develop and how to advance personalised veterinary healthcare.MethodsAt regular intervals, extensive diet, health and lifestyle information, electronic medical records, clinicopathology and activity data are collected, genotypes, whole genome sequences and faecal metagenomes analysed, and blood, plasma, serum, and faecal samples stored for future research.DiscussionProposed areas for research include the early detection and progression of age-related disease, risk factors for common conditions, the influence of the microbiome on health and disease and, through genome wide association studies, the identification of candidate loci for disease associated genetic variants. Genomic data will be open access and research proposals for access to data and samples will be considered. Over the coming years, the MPB will provide the longitudinal data and systematically collected biological samples required to generate important insights into companion animal health, identifying biomarkers of disease, supporting earlier identification of risk, and enabling individually tailored interventions to manage disease.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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