Protective effects of paraoxonase-1, vitamin E and selenium, and oxidative stress index on the susceptibility of low density lipoprotein to oxidation in diabetic patients with/without coronary artery disease

European Journal of Medical Research

Research

Nafiseh Khansari¹  Behnoosh Ansari Asl¹  Ali Khosrowbeygi²  Fatemeh Imanparast²  Abbas Alimoradian³  Pegah Mohaghegh⁴  Fatemeh Mehvari⁵ 

[1] A Food and Drug Deputy, Arak University of Medical Sciences, Arak, Iran;Department of Biochemistry and Genetics, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran;Department of Pharmacology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran;Depertment of community medicine school of medicine, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran;Student Research Committee, Arak University of Medical Sciences, Arak, Iran;

关键词: Diabetes mellitus;    Coronary artery disease;    Oxidative stress;    Vitamin E;    Selenium;    Oxidized low density lipoprotein;    Paraoxonase-1;   

DOI  :  10.1186/s40001-023-01254-9

 received in 2023-05-21, accepted in 2023-07-29,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe oxidative modification of low density lipoprotein (LDL) is closely associated with an increased risk for coronary artery disease (CAD) in diabetic patients. The purpose of this study is to investigate the relation between serum vitamin E and selenium, paraoxonase-1 (PON1) activity, total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), and oxidative stress index (OSI) values with the susceptibility of LDL to oxidative modification and the possibility of CAD in diabetic patients.MethodThis study was designed as a case control survey of 82 diabetes patients divided into two groups including T2DM alone (as group I) and both T2DM and CAD (as group II). Fasting blood samples were taken to the assay of fasting blood glucose (FBG), HbA1c, total cholesterol (TC), TAC, TOS, MDA, OSI, vitamin E, selenium, oxidized low density lipoprotein (Ox-LDL), and activity of PON1.ResultsOx-LDL, MDA, TOS, and OSI values in groups II were significantly higher compared with group I (all with P value = 0.000). TAC, vitamin E, selenium, and PON1 activity values were significantly lower in group II compared with groups I (P value = 0.000; P value = 0.000; P value = 0.007; P value = 0.003, respectively). There were significant relationships between the amounts of TAC, TOS, OSI, and vitamin E with the amounts of PON1 activity and Ox-LDL (p < 0.05). But Ox-LDL and PON1 activity correlated weakly with together (p = 0.094).ConclusionResults of this study support the belief that oxidative stress might be an important etiologic factor which makes some diabetics more susceptible to CAD. Increased oxidative stress may be a potential therapeutic target in the prevention and management of CAD in diabetic patients.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023