Heterotopia of salivary gland tissue in the pancreas

Diagnostic Pathology

Case Report

Catharina Olsen¹  Pierre Lefesvre²  Ilse Rooman³  Katarina Coolens³  Sandrina Martens⁴ 

[1] Brussels Interuniversity Genomics High Throughput Core (BRIGHTcore), VUB-ULB, Brussels, Belgium;Clinical Sciences, Research Group Reproduction and Genetics, Centre for Medical Genetics, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium;Interuniversity Institute of Bioinformatics in Brussels (IB)2, VUB-ULB, Brussels, Belgium;Department of Pathology, UZ Brussel, Brussels, Belgium;Laboratory of Medical and Molecular Oncology, Vrije Universiteit Brussel (VUB), Brussels, Belgium;Laboratory of Medical and Molecular Oncology, Vrije Universiteit Brussel (VUB), Brussels, Belgium;Department of Cardio and Organ Systems, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium;

关键词: Heterotopia;    Salivary gland;    Submandibular gland;    Pancreas;    Ectopia;   

DOI  :  10.1186/s13000-023-01385-x

 received in 2023-04-21, accepted in 2023-08-20,  发布年份 2023

来源: Springer

【 摘 要 】

Heterotopia of the salivary gland occurs mainly in the head and neck region of the human body, rarely in regions such as the rectum, but has never been demonstrated in the pancreas. Within a screening effort of pancreatic samples for detecting ΔNp63 expression, we discovered two pancreatic samples from a 35-year-old male showing salivary gland heterotopia. Immunohistochemical stainings were done for markers of healthy and neoplastic salivary glands and showed expression of calponin, CD142 and KRT14 but not of S100p, GFAP or CD117. A PAS-staining and Alcian Blue staining showed the presence of acid mucins. These staining patterns were consistent with non-neoplastic submandibular gland tissue comprised of abundant seromucous glands, basal cells and myoepithelial cells, all features typically absent in the pancreas. Also, no pancreatic islets of Langerhans were detected. We show for the first time that salivary gland heterotopia can occur at the location of the pancreas.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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