Large cell neuroendocrine carcinoma presenting with neck swelling in the submandibular gland: a case report

Journal of Medical Case Reports

Hiroshi Fukui¹  Kousaku Morita²  Hitoshi Yoshiji¹  Yusaku Shirai¹  Fumi Kawanami¹  Masaaki Yoshikawa¹  Tatsuhiro Tsujimoto¹  Hideto Kawaratani¹ 

[1] Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan;Department of Diagnostic Pathology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan

关键词: Submandibular gland;    Salivary gland;    Large cell neuroendocrine carcinoma;    Autopsy;   

Others  :  1181238
DOI  :  10.1186/1752-1947-7-81

 received in 2012-08-14, accepted in 2013-02-12,  发布年份 2013

【 摘 要 】

Introduction

Large cell neuroendocrine carcinoma in the salivary glands is rare. We report a second case of large cell neuroendocrine carcinoma of the submandibular gland diagnosed at autopsy, and a review of the literature.

Case presentation

A 68-year-old Japanese man was referred to our hospital for thorough investigation of swelling on the right side of his neck. Fine-needle aspiration cytology of the cervical mass suggested poorly differentiated metastatic carcinoma. The primary tumor could not be detected by several examinations. One month after admission, he died of cancer. An autopsy was performed, and it revealed a tumor of the right submandibular gland. The histopathological diagnosis was large cell neuroendocrine carcinoma of the submandibular gland.

Conclusion

To the best of our knowledge, only eight cases of large cell neuroendocrine carcinoma in the salivary glands, including our case, have been reported. This report indicates total biopsy and immunohistochemistry are necessary for diagnosing large cell neuroendocrine carcinoma properly.

【 授权许可】

   
2013 Kawaratani et al.; licensee BioMed Central Ltd.

【 图 表 】

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