Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent

European Journal of Medical Research

Review

Sheng Nie¹  Shengjun Zhou¹  Chenhui Zhou²  Yi Huang²  Xiang Gao²  Gao Chen³ 

[1] Department of Neurosurgery, Ningbo First Hospital, 315300, Ningbo, China;School of Medicine, Zhejiang University, 310009, Hangzhou, China;Department of Neurosurgery, Ningbo First Hospital, 315300, Ningbo, China;School of Medicine, Zhejiang University, 310009, Hangzhou, China;Department of Neurosurgery, School of Medicine, Second Affiliated Hospital, Zhejiang University, Hangzhou, China;

关键词: Fisetin;    Cancer;    Anticancer therapy;    Biological function;    Signal pathways;   

DOI  :  10.1186/s40001-023-01271-8

 received in 2023-07-10, accepted in 2023-08-07,  发布年份 2023

来源: Springer

【 摘 要 】

Fisetin, a natural flavonoid, possesses numerous biological activities that have been extensively studied in various diseases. When it comes to cancer, fisetin exhibits a range of biological effects, such as suppressing cell growth, triggering programmed cell death, reducing the formation of new blood vessels, protecting against oxidative stress, and inhibiting cell migration. Moreover, fisetin has the ability to enhance the effectiveness of chemotherapy. The anticancer properties of fisetin can be attributed to a diverse array of molecules and signaling pathways, including vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB), PI3K/Akt/mTOR, and Nrf2/HO-1. Consequently, fisetin holds promise as a therapeutic agent for anticancer treatment. In this review, we place emphasis on the biological functions and various molecular targets of fisetin in anticancer therapy.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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