Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer

Experimental Hematology & Oncology

Shaoqing Ju¹  Yuejiao Huang²  Shuo Ma²  Yu Zhang²  Xinliang Gu²  Xinyue Qin² 

[1] Department of Laboratory Medicine, Affiliated Hospital of Nantong University;Medical School of Nantong University, Nantong University;

关键词: tRNAs;    tsRNAs;    Biological function;    Cancer;    Biomarker;   

DOI  :  10.1186/s40164-022-00290-1

来源: DOAJ

【 摘 要 】

Abstract Transfer RNAs (tRNAs) promote protein translation by binding to the corresponding amino acids and transporting them to the ribosome, which is essential in protein translation. tRNA-derived small RNAs (tsRNAs) are derived fragments of tRNAs that are cleaved explicitly under certain conditions. An increasing amount of research has demonstrated that tsRNAs have biological functions rather than just being degradation products. tsRNAs can exert functions such as regulating gene expression to influence cancer progression. Their dysregulation is closely associated with various cancers and can serve as diagnostic and prognostic biomarkers for cancer. This review summarizes the generation, classification, and biological functions of tsRNAs, and highlights the roles of tsRNAs in different cancers and their applications as tumor markers.

【 授权许可】

Unknown