Virology Journal | |
Neutrophils in COVID-19: recent insights and advances | |
Review | |
Jiayu Li1  Changxing Huang1  Kegong Zhang1  ye Zhang1  Ziyang Gu1  | |
[1] Department of Infectious Diseases, Second Affiliated Hospital of Air Force Military Medical University, 710038, Xi’an, China; | |
关键词: COVID-19; Neutrophils; Neutrophil extracellular traps (NETs); Low- density neutrophils (LDNs); Cytokine storm; Thrombosis; Treatment strategies; | |
DOI : 10.1186/s12985-023-02116-w | |
received in 2023-03-10, accepted in 2023-07-06, 发布年份 2023 | |
来源: Springer | |
【 摘 要 】
Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to acute respiratory distress syndrome (ARDS), multi-organ failure and death, posing significant threat to human health. Studies have found that pathological mechanisms, such as cytokine storms caused by uncontrolled innate immune system activation, release of damage-associated molecular patterns during tissue injury and a high incidence of thrombotic events, are associated with the function and dysfunction of neutrophils. Specifically, the increased formation of low-density neutrophils (LDNs) and neutrophil extracellular traps (NETs) has been shown to be closely linked with the severity and poor prognosis in patients with COVID-19. Our work focuses on understanding the increased number, abnormal activation, lung tissue infiltration, and elevated neutrophil-to-lymphocyte ratio in the pathogenesis of COVID-19. We also explore the involvement of NETs and LDNs in disease progression and thrombosis formation, along with potential therapeutic strategies targeting neutrophil and NETs formation.
【 授权许可】
CC BY
© The Author(s) 2023
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202309151695078ZK.pdf | 1120KB | download | |
Fig. 1 | 424KB | Image | download |
Fig. 3 | 346KB | Image | download |
【 图 表 】
Fig. 3
Fig. 1
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]
- [31]
- [32]
- [33]
- [34]
- [35]
- [36]
- [37]
- [38]
- [39]
- [40]
- [41]
- [42]
- [43]
- [44]
- [45]
- [46]
- [47]
- [48]
- [49]
- [50]
- [51]
- [52]
- [53]
- [54]
- [55]
- [56]
- [57]
- [58]
- [59]
- [60]
- [61]
- [62]
- [63]
- [64]
- [65]
- [66]
- [67]
- [68]
- [69]
- [70]
- [71]
- [72]
- [73]
- [74]
- [75]