Evaluation of psychological distress is essential for patients with locally advanced breast cancer prior to neoadjuvant chemotherapy: baseline findings from cohort study

BMC Women's Health

Research

Yazeed A. Al-Sheikh¹  Mourad A.M. Aboul-Soud¹  Lamiae Amaadour²  Nawfel Mellas²  Zineb Benbrahim²  Salima Kriya³  Sara Nadi³  Karima El Rhazi⁴  Achraf El Asri⁴  Btissame Zarrouq⁵  Majid Omari⁶  Mohammed El Amine Ragala⁷  Karima Halim⁸  Jaouad El Hilaly⁹  John P. Giesy^1,10 

[1] Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, 11433, Riyadh, Saudi Arabia;Department of Medical Oncology, Hassan II University Hospital, Fez, Morocco;Higher Institute of Nursing Professions and Health Techniques, Fez, Morocco;Laboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdallah University, Fez, Morocco;Laboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdallah University, Fez, Morocco;Department of Biology and Geology, Teacher’s Training College (Ecole Normale Supérieure), Sidi Mohamed Ben Abdallah University, Fez, Morocco;Laboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdallah University, Fez, Morocco;Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health & Quality of Life, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco;Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health & Quality of Life, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco;Department of Biology and Geology, Teacher’s Training College (Ecole Normale Supérieure), Sidi Mohamed Ben Abdallah University, Fez, Morocco;Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health & Quality of Life, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco;Department of Human and Social Sciences - Education Sciences, Teachers Training College (Ecole Normale Superieure), Sidi Mohamed Ben Abdellah University, Fez, Morocco;Laboratory of Pedagogical and Didactic Engineering of Sciences and Mathematics, Regional Center of Education and Training (CRME F) of Fez, Fez, Morocco;R.N.E Laboratory, Multidisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University, Fez, Morocco;Toxicology Centre, University of Saskatchewan, S7N 5B3, Saskatoon, SK, Canada;Department of Veterinary Biomedical Sciences, University of Saskatchewan, S7N 5B4, Saskatoon, SK, Canada;Department of Integrative Biology, Michigan State University, 48824, East Lansing, MI, USA;Department of Environmental Sciences, Baylor University, 76706, Waco, TX, USA;

关键词: Psychological distress;    Depression;    Anxiety;    Sociodemographic factors;    Clinical factors;    Locally advanced breast cancer;    Neoadjuvant chemotherapy;   

DOI  :  10.1186/s12905-023-02571-1

 received in 2023-05-08, accepted in 2023-07-25,  发布年份 2023

来源: Springer

【 摘 要 】

Backgroundpatients with locally advanced breast cancer (LABC) are often treated by neoadjuvant chemotherapy (NACT). This study aims to determine the prevalence of psychological distress and their sociodemographic and clinical factors in patients recently diagnosed with LABC and before NACT. Methods: A total of 209 LABC patients without metastatic localization were recruited between 2021 and 2022 in the oncology hospital at Fez. A structured questionnaire and the Hospital Anxiety and Depression Scale were used. A descriptive analysis and linear model were performed. Results: a mean age of participants was 47.43 ± 9.45 years. The prevalence of depression, anxiety and psychological distress among participants was 59.62% (95% CI: 52.61–33.34), 47.85% (95% CI: 40.91–54.85), and 65.07 (95% CI: 58.19–71.52) respectively. Depression was associated to age (< 50 years) (AOR = 2.19; 95% CI = 1.13–4.23) and health insurance (AOR = 3.64; 95% CI: 1.18–11.26). Anxiety was associated to age (< 50) (AOR = 2.21; 95% CI: 1.18–4.13) and right breast cancer (AOA = 2.01; 95% CI: 1.11–3.65). Psychological distress was associated to chronic illness (AOR = 2.78; 95% CI: 1.32–5.85) and lymph node status (AOR = 2.39; 95% CI: 1.26–4.57). Conclusions: Based on the high prevalence of depression and anxiety it appears opportune to treat psychological distress among LABC patient candidates for NACT. Each psychological intervention should take into account sociodemographic and clinical factors found associated in our study. Psychological therapeutic interventions are crucial for LABC patients as early as the time of diagnosis and through subsequent steps in NACT to improve their overall mental health.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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