Glioma-BioDP: database for visualization of molecular profiles to improve prognosis of brain cancer

BMC Medical Genomics

Database

Shaoli Das¹  Harpreet Kaur²  Xiang Deng²  Kevin Camphausen²  Evan Wilson²  Uma Shankavaram² 

[1] Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA;Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, CRC, Rm B2-3561, 20892, Bethesda, MD, USA;

关键词: Brain cancer;    Glioma;    Database;    Multi-omics;   

DOI  :  10.1186/s12920-023-01593-w

 received in 2022-10-03, accepted in 2023-06-26,  发布年份 2023

来源: Springer

【 摘 要 】

Cancer researchers often seek user-friendly interactive tools for validation, exploration, analysis, and visualization of molecular profiles in cancer patient samples. To aid researchers working on the both low- and high-grade gliomas, we developed Glioma-BioDP, a web tool for exploration and visualization of RNA and protein expression profiles of interest in these tumor types. Glioma-BioDP is user friendly application that include expression data from both the low- and high-grade glioma patient samples from The Cancer Genome Atlas and enabled querying by mRNA, microRNA, and protein level expression data from Illumina HiSeq and RPPA platforms respectively. Glioma-BioDP provides advance query interface and enables users to explore the association of genes, proteins, and miRNA expression with molecular and/or histological subtypes of gliomas, surgical resection status and survival. The prognostic significance and visualization of the selected expression profiles can be explored using interactive utilities provided. This tool may also enable validation and generation of new hypotheses of novel therapies impacting gliomas that aid in personalization of treatment for optimum outcomes.

【 授权许可】

CC BY   
© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

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