Eczema as a protective factor for brain cancer: a meta-analysis

BMC Cancer

Research

Jie Liu¹  Boheng Zhu¹  Yinde Xu¹  Weimin Yan²  Shuangyan Xu²  Yun Zhu³  Yirong Teng⁴ 

[1] Department of Dermatology and Venereology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China;Department of Dermatology and Venereology, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, Yunnan, China;Department of Dermatology and Venereology, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, Yunnan, China;Department of Dermatology and Venereology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China;Department of General Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, Yunnan, China;

关键词: Eczema;    Brain cancer;    Glioma;    Meningioma;    Acoustic neuroma;    Risk;   

DOI  :  10.1186/s12885-022-10471-0

 received in 2022-09-24, accepted in 2022-12-21,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundBrain cancer is one of the most aggressive cancer types owing to poor treatment effects. Epidemiological studies have demonstrated that allergies may increase the disease risk. Therefore, this study evaluated the association between eczema and the risk of various brain cancers.MethodsWe systematically searched the PubMed and Embase databases from their inception until June 23, 2022. Two reviewers independently reviewed and screened the articles, extracted data, assessed the study quality, and pooled the results. Stata software was used to generate pooled odds ratios and 95% confidence intervals (CIs).ResultsWe included 20 studies comprising 5,117,222 patients that investigated the relationship between eczema and brain cancer. Eczema was significantly inversely associated with the risk of brain cancer (odds ratio [OR], 0.82; 95% CI, 0.77–0.87), glioma (OR, 0.53; 95% CI, 0.14–2.02), meningioma (OR, 0.74; 95% CI, 0.66–0.84), and acoustic neuroma (OR, 0.60; 95% CI, 0.41–0.88). Interesting, The strong correlation between eczema and the reduced risk of brain cancer was observed in people over 16 years old (OR, 0.79; 95% CI, 0.71–0.88), but not in those under 16 years old (OR, 0.94; 95% CI, 0.79–1.11). In addition, subgroup analyses found that eczema significantly decreased the glioma risk in Europeans (OR, 0.73; 95% CI, 0.65–0.82) but not Australians (OR, 0.53; 95% CI, 0.14–2.02) or Americans (OR, 1.01; 95% CI, 0.69–1.46).ConclusionEczema may be considered as a potential protective factor of brain cancer in population aged over 16 years. However, this relationship requires verification using large-scale clinical data.

【 授权许可】

CC BY   
© The Author(s) 2022

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