Single-cell RNA sequencing for the study of kidney disease

Molecular Medicine

Review

Jiayi Zhu¹  Huachun Weng¹  Jinrong Lu¹ 

[1] The College of Medical Technology, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Highway, Pudong New Area, 201318, Shanghai, China;

关键词: Kidney disease;    scRNA-seq;    Pathogenesis;   

DOI  :  10.1186/s10020-023-00693-8

 received in 2023-01-14, accepted in 2023-06-27,  发布年份 2023

来源: Springer

【 摘 要 】

The kidney is an important organ for maintaining normal metabolism and stabilising the internal environment, in which, the heterogeneity of cell types has hindered the progress in understanding the mechanisms underlying kidney disease. In recent years the application of single-cell RNA sequencing (scRNA-seq) in nephrology has developed rapidly. In this review, we summarized the technical platform related to scRNA-seq and the role of this technology in investigating the onset and development of kidney diseases, starting from several common kidney diseases (mainly including lupus nephritis, renal cell carcinoma, diabetic nephropathy and acute kidney injury), and provide a reference for the application of scRNA-seq in the study of kidney disease diagnosis, treatment and prognosis.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 8