Exploring the potential of microRNA as a diagnostic tool for gestational diabetes

Journal of Translational Medicine

Review

Souhaila Al Khodor¹  Duaa Ahmed Elhag¹ 

[1] Maternal and Child Health Division, Research Branch, Sidra Medicine, Doha, Qatar;

关键词: Diabetes;    OGTT;    Pregnancy complications;    BMI;    Macrosomia;   

DOI  :  10.1186/s12967-023-04269-2

 received in 2023-04-26, accepted in 2023-06-11,  发布年份 2023

来源: Springer

【 摘 要 】

MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in regulating host gene expression. Recent studies have indicated a role of miRNAs in the pathogenesis of gestational diabetes mellitus (GDM), a common pregnancy-related disorder characterized by impaired glucose metabolism. Aberrant expression of miRNAs has been observed in the placenta and/or maternal blood of GDM patients, suggesting their potential use as biomarkers for early diagnosis and prognosis. Additionally, several miRNAs have been shown to modulate key signaling pathways involved in glucose homeostasis, insulin sensitivity, and inflammation, providing insights into the pathophysiology of GDM. This review summarizes the current knowledge on the dynamics of miRNA in pregnancy, their role in GDM as well as their potential as diagnostic and therapeutic targets.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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