Cross-reactive immune responses to monkeypox virus induced by MVA vaccination in mice

Virology Journal

Research

Fangjingwei Xu¹  Cheng He²  Feixia Gao²  Min Liu²  Linya Zhang²  Shihua Tian²  Mei Zheng²  Jian Luo²  Xiuling Li²  Ping Yuan²  Xu Zhou² 

[1] China National Biotec Group, Beijing, China;Shanghai Institute of Biological Products, Shanghai, China;

关键词: MVA;    Monkeypox virus;    Protective antigens;    Humoral immune response;    Cellular immune response;   

DOI  :  10.1186/s12985-023-02085-0

 received in 2023-02-23, accepted in 2023-05-28,  发布年份 2023

来源: Springer

【 摘 要 】

Mpox (monkeypox) infection cases increased recently in non-Mpox outbreak areas, potentially causing an international threat. The desire to defend against a potential outbreak has led to renewed efforts to develop Mpox vaccines. In this report, mice were immunized with various doses of modified vaccinia virus Ankara (MVA) to evaluate the cross-reactive immune response of MVA immunization against protective antigens of the current monkeypox virus. We demonstrated that MVA induced specific antibodies against protective antigens (A29, A35, B6, M1, H3, and I1), mediating the neutralization abilities against the MVA and the monkeypox virus (MPXV). Moreover, recombinant protective antigens of the MPXV elicited cross-binding and cross-neutralizing activities for MVA. Hence, the MVA induced cross-reactive immune responses, which may guide future efforts to develop vaccines against the recent MPXV. Notably, compared to the other protective antigens, the predominant A29 and M1 antigens mediated higher cross-neutralizing immune responses against the MVA, which could serve as antigen targets for novel orthologous orthopoxvirus vaccine.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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