Molecular mechanisms of tumor resistance to radiotherapy

Molecular Cancer

Review

Yingqiu Song¹  Tianlu Wang²  Runze Wang³  Yu Wu³ 

[1] Department of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, No.44 Xiaoheyan Road, Dadong District, 110042, Shenyang, Liaoning Province, China;Department of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, No.44 Xiaoheyan Road, Dadong District, 110042, Shenyang, Liaoning Province, China;Faculty of Medicine, Dalian University of Technology, 116024, Dalian, China;Department of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, No.44 Xiaoheyan Road, Dadong District, 110042, Shenyang, Liaoning Province, China;School of Graduate, Dalian Medical University, 116044, Dalian, China;

关键词: Cancer;    Radiotherapy;    Tumor resistance;   

DOI  :  10.1186/s12943-023-01801-2

 received in 2023-01-03, accepted in 2023-06-03,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundCancer is the most prevalent cause of death globally, and radiotherapy is considered the standard of care for most solid tumors, including lung, breast, esophageal, and colorectal cancers and glioblastoma. Resistance to radiation can lead to local treatment failure and even cancer recurrence.Main bodyIn this review, we have extensively discussed several crucial aspects that cause resistance of cancer to radiation therapy, including radiation-induced DNA damage repair, cell cycle arrest, apoptosis escape, abundance of cancer stem cells, modification of cancer cells and their microenvironment, presence of exosomal and non-coding RNA, metabolic reprogramming, and ferroptosis. We aim to focus on the molecular mechanisms of cancer radiotherapy resistance in relation to these aspects and to discuss possible targets to improve treatment outcomes.ConclusionsStudying the molecular mechanisms responsible for radiotherapy resistance and its interactions with the tumor environment will help improve cancer responses to radiotherapy. Our review provides a foundation to identify and overcome the obstacles to effective radiotherapy.

【 授权许可】

CC BY   
© The Author(s) 2023

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