Recent advances in radiotherapy and its associated side effects in cancer—a review

Journal of Basic and Applied Zoology

Saradha Devi K M¹  Arul Narayanasamy²  Ayisha Hamna T P³  Balachandar Vellingiri³  Gomathi Mohan³  Jijo A J⁴ 

[1] Department of Biochemistry, Bharathiar University;Disease Proteomics Laboratory, Department of Zoology, Bharathiar University;Human Molecular Genetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University;Post Graduate and Research Department of Zoology, Sree Narayana College;

关键词: Radiotherapy;    Mutational changes;    Infertility;    Secondary malignancy;    Cancer;   

DOI  :  10.1186/s41936-019-0083-5

来源: DOAJ

【 摘 要 】

Abstract Background Radiotherapy (RT) is the chief nonsurgical method to control malignant tumors. RT has advanced in both methodological and biological aspects over the past few decades. Though RT is a momentous adjuvant non-invasive technique, it leaves behind some unsympathetic effects. Research is going on to surmount these pessimistic sides of RT. Methods We made a mini review of recent articles from the period of 2000 to 2017 regarding radiotherapy and its side effects in various types of cancers. The literature review was done by searching in PUBMED, MEDLINE, and SCOPUS. Results Here, we spotlight the physiological and genetic risks associated with the cancer patients undergoing RT. We illustrated the course of RT in most prevalent cancers tailored with dosage distribution. Radiation-induced mutation in the patients undergoing RT has been shown with evidence. Further, the major drawbacks like the development of radiation resistance in cancerous cells and secondary malignancies have been discussed. The problems associated with radiation dosage in terms of infertility and rejuvenation of reproductive cells has also been discussed. Finally, we discussed the latest treatment stratagem of RT in cancer. Conclusion Cancer treatment will not be accomplished devoid of radiotherapy. But we can brace RT using radiosensitizers and ayurvedic radioprotectors.

【 授权许可】

Unknown