Health-related quality of life and radiological and functional lung changes of patients with COVID-19 Pneumonia 3 and 10 months after discharge

BMC Pulmonary Medicine

Research

Marta Acosta¹  Sergio Calvache¹  Cristina De Juana¹  Loubna Dahmazi¹  Eva Martínez-Moragón¹  Susana Herrera¹  Silvia Ponce¹  Irene López¹  Verónica Valentín¹  Alberto José Ferrer²  Raffaele Vitale³ 

[1] Department of Respiratory Medicine, Universitary Hospital Doctor Peset of Valencia, Valencia, Spain;Polytechnic University of Valencia, Valencia, Spain;University of Lille, CNRS, LASIRE, Lille, France;

关键词: COVID-19;    Health-related quality of life;    Follow-up radiological findings and pulmonary function;   

DOI  :  10.1186/s12890-023-02520-6

 received in 2023-04-28, accepted in 2023-06-15,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundFew studies have evaluated the long-term impact on health-related quality of life (HRQoL) in patients who have been hospitalized for COVID-19 pneumonia. Specific follow-up should be carried out to detect and treat possible pulmonary abnormalities, and the worsening of HRQoL should be estimated to target necessary resources for care of these patients after acute phase. The objective was to know the impact on HRQoL of patients who have been admitted for COVID-19 pneumonia, and to evaluate the clinical-radiological and functional changes of patients who have overcome COVID-19 pneumonia at 3 and 10 months of follow-up.MethodsProspective observational study of patients who required hospitalization for COVID-19 pneumonia between April and December 2020. All patients filled out the EuroQol five-dimension (EQ-5D) questionnaire with the EuroQol Visual Analogue Scale (E-VAS) for self-assessment of health status. Respiratory function tests and chest X-ray were carried out at 3 and 10 months of follow-up.Results61 patients were included in the study. The need for ventilatory support was associated with anxiety/depression on the EQ-5D scale, as well as patients admitted to the intensive care unit (ICU). The mean EQ-5D and E-VAS index scores decreased with hospitalization time, the number of days spent in intermediate respiratory care unit (IRCU) and the level of dyspnoea at the beginning of the hospitalization period. Pulmonary sequelae were observed in 25 patients (41%) at 3 months and 17 (27.9%) at 10 months. Patients improve their forced vital capacity (FVC) by 196 ml (p = 0.001) at 10 months as well as 9% in diffusing capacity of lung for carbon monoxide (DLCO) (p = 0.001) at 10 months. DLCO was found to be correlated to lymphopenia and time spent in IRCU. Low FVC values were detected 10 months after discharge for subjects exhibiting high levels of dyspnoea at 3 months after discharge.ConclusionsHospitalization for COVID-19 pneumonia affects the HRQoL of patients, with greater anxiety/depression in those who were more serious affected and are younger. A significant percentage of patients present fibrotic abnormalities and lung function impairment at the first and second follow-up after discharge.

【 授权许可】

CC BY   
© The Author(s) 2023

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