COVID-19 does not influence functional status after ARDS therapy

Critical Care

Research

Valbona Mirakaj¹  Helene Anna Haeberle¹  Alice Bernard¹  Michael Koeppen¹  Peter Rosenberger¹  Christian Putensen²  Alexander Zarbock³  Gernot Marx⁴  Peter Martus⁵  Lina Maria Serna-Higuita⁵ 

[1] Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Universitätsklinikum Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany;Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany;Department of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany;Department of Intensive Care Medicine, University Hospital RWTH Aachen, Aachen, Germany;Institute for Clinical Epidemiology and Applied Biometry, Faculty of Medicine, University of Tübingen, Tübingen, Germany;

关键词: COVID-19;    Barthel index;    Health-related quality of life;    Viral pneumonia;   

DOI  :  10.1186/s13054-023-04330-y

 received in 2022-11-11, accepted in 2023-01-22,  发布年份 2023

来源: Springer

【 摘 要 】

RationaleHealth-related quality of life after surviving acute respiratory distress syndrome has come into focus in recent years, especially during the coronavirus disease 2019 pandemic.ObjectivesA total of 144 patients with acute respiratory distress syndrome caused by COVID-19 or of other origin were recruited in a randomized multicenter trial.MethodsClinical data during intensive care treatment and data up to 180 days after study inclusion were collected. Changes in the Sequential Organ Failure Assessment score were used to quantify disease severity. Disability was assessed using the Barthel index on days 1, 28, 90, and 180.MeasurementsMortality rate and morbidity after 180 days were compared between patients with and without COVID-19. Independent risk factors associated with high disability were identified using a binary logistic regression.Main resultsThe SOFA score at day 5 was an independent risk factor for high disability in both groups, and score dynamic within the first 5 days significantly impacted disability in the non-COVID group. Mortality after 180 days and impairment measured by the Barthel index did not differ between patients with and without COVID-19.ConclusionsResolution of organ dysfunction within the first 5 days significantly impacts long-term morbidity. Acute respiratory distress syndrome caused by COVID-19 was not associated with increased mortality or morbidity.

【 授权许可】

CC BY   
© The Author(s) 2023

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