Encapsulated peracetic acid as a valid broad-spectrum antimicrobial alternative, leading to beneficial microbiota compositional changes and enhanced performance in broiler chickens

Journal of Animal Science and Biotechnology

Research

Leah Conway¹  Adrian Fellows¹  Nikki Dalby²  Salvatore Galgano³  Jos G. M. Houdijk³ 

[1] Aga2tech Ltd, Halifax, UK;Centre for Innovation Excellence in Livestock, York, UK;Monogastric Science Research Centre, Scotland’s Rural College, West Mains Road, EH9 3JG, Edinburgh, Scotland, UK;

关键词: Antimicrobial alternative;    Antimicrobial resistance;    Broiler chicken;    Microbiota;    Peracetic acid;    Performance;    16S rRNA gene;   

DOI  :  10.1186/s40104-023-00881-w

 received in 2022-12-22, accepted in 2023-04-10,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAntimicrobial alternatives are urgently needed, including for poultry production systems. In this study, we tested the potential broad-range antimicrobial alternative peracetic acid, delivered in feed via the hydrolysis of encapsulated precursors through a 28-day study using 375 Ross 308 broiler chickens. We tested two peracetic acid concentrations, 30 and 80 mg/kg on birds housed on re-used litter, and we evaluated the impact of both levels on gut microbial communities, bacterial concentration, antimicrobial resistance genes relative abundance and growth performance when compared to control birds housed on either clean or re-used litter.ResultsBody weight gain and feed conversion ratio improved in peracetic acid fed birds. At d 28, birds given 30 mg/kg of peracetic acid had a decreased Firmicutes and an increased Proteobacteria abundance in the jejunum, accompanied by an increase in Bacillus, Flavonifractor and Rombustia in the caeca, and a decreased abundance of tetracycline resistance genes. Chicken given 80 mg/kg of peracetic acid had greater caecal abundance of macrolides lincosamides and streptogramins resistance genes. Growth performance on clean litter was reduced compared to re-used litter, which concurred with increased caecal abundance of Blautia, decreased caecal abundance of Escherichia/Shigella, Anaerostipes and Jeotgalicoccus, and greater gene abundance of vancomycin, tetracycline, and macrolides resistance genes.ConclusionsPeracetic acid could be used as a safe broad-spectrum antimicrobial alternative in broilers. Encapsulated precursors were able to reduce the bacterial concentration in the jejunum whilst promoting the proliferation of probiotic genera in the caeca, especially at the low peracetic acid concentrations tested, and improve growth performance. Moreover, our findings offer further insights on potential benefits of rearing birds on re-used litter, suggesting that the latter could be associated with better performance and reduced antimicrobial resistance risk compared to clean litter rearing.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 1

40517_2023_252_Article_IEq62.gif

Fig. 2

40517_2023_252_Article_IEq55.gif

40517_2023_252_Article_IEq51.gif

40517_2023_252_Article_IEq37.gif