The emerging studies on mesenchymal progenitors in the long bone

Cell & Bioscience

Review

Xiaobin Huang¹  Guangxu He²  Fangyuan Shen³  Yu Shi³ 

[1] Department of Oral and Maxillofacial Surgery/Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA;Department of Orthopedics, The Second Xiangya Hospital, Central South University, NO. 139 Middle Renmin Road, Changsha, Hunan, China;State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China;

关键词: Mesenchymal progenitors;    Bone development;    Bone regeneration;   

DOI  :  10.1186/s13578-023-01039-x

 received in 2022-12-29, accepted in 2023-05-01,  发布年份 2023

来源: Springer

【 摘 要 】

Mesenchymal progenitors (MPs) are considered to play vital roles in bone development, growth, bone turnover, and repair. In recent years, benefiting from advanced approaches such as single-cell sequence, lineage tracing, flow cytometry, and transplantation, multiple MPs are identified and characterized in several locations of bone, including perichondrium, growth plate, periosteum, endosteum, trabecular bone, and stromal compartment. However, although great discoveries about skeletal stem cells (SSCs) and progenitors are present, it is still largely obscure how the varied landscape of MPs from different residing sites diversely contribute to the further differentiation of osteoblasts, osteocytes, chondrocytes, and other stromal cells in their respective destiny sites during development and regeneration. Here we discuss recent findings on MPs’ origin, differentiation, and maintenance during long bone development and homeostasis, providing clues and models of how the MPs contribute to bone development and repair.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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