Hic1 deletion unleashes quiescent connective tissue stem cells and impairs skeletal muscle regeneration

Journal of Cell Communication and Signaling

article

Contreras, Osvaldo¹ 

[1] Departamento de Biología Celular y Molecular, Pontificia Universidad Católica de Chile

关键词: Fibro-adipogenic progenitors;    Fibroblasts;    Wound healing;    Fibrosis;    Mesenchymal stromal cells;    Mesenchymal progenitors;    Quiescence;   

DOI  :  10.1007/s12079-019-00545-3

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Skeletal muscle fibro-adipogenic progenitors (FAPs) are tissue-resident connective tissue cells and the main cellular source of pathological fibro-fatty scar associated with muscle disorders. Although our knowledge about skeletal muscle mesenchymal progenitor cells has exploded in the past decade, we still lack information about their origin, fate, gene regulation, function, and stemness. A recent study by Underhill and colleagues, published in Cell Stem Cell, described the last census of Hic1 mesenchymal progenitor/stem cells in skeletal muscle regeneration, providing valuable results and data to the ever-expanding community of scientists interested in tissue regeneration and fibrosis. This commentary contextualizes and summarizes these exciting new findings.

【 授权许可】

CC BY