Long term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antivirals

BMC Gastroenterology

Research

Kengo Kawai¹  Yukihiro Shimizu¹  Yoshiro Kashii²  Hiroyuki Ito³  Yoshiharu Tokimitsu⁴  Kazuhiko Okada⁴  Yuka Hayashi⁵  Nozomu Muraishi⁵  Ichiro Yasuda⁵  Terumi Takahara⁵  Masami Minemura⁵  Aiko Murayama⁵  Kazuto Tajiri⁵ 

[1] Gastroenterology, Nanto Municipal Hospital, 932-0211, Nanto, Japan;Gastroenterology, Saiseikai Toyama Hospital, 931-8533, Toyama, Japan;Gastroenterology, Takaoka Municipal Hospital, 933-8550, Takaoka, Japan;Gastroenterology, Toyama Red Cross Hospital, 930-8562, Toyama, Japan;Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, 930-0194, Toyama, 2630 Sugitani, Japan;

关键词: Hepatitis C virus;    Thrombocytopenia;    Hypersplenism;    Direct-acting antiviral;   

DOI  :  10.1186/s12876-023-02829-w

 received in 2022-10-11, accepted in 2023-05-22,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThrombocytopenia due to hypersplenism is a major complication of hepatitis C virus (HCV)-associated cirrhosis. HCV eradication improves these complications in some patients, but the long-term effects of HCV eradication on these complications remain unclear, especially in patients treated with direct acting antivirals (DAAs). The aim was to evaluate long term changes in thrombocytopenia and leucopenia after HCV eradication with DAAs.MethodsThe present multicenter study retrospectively evaluated changes over 5 years in thrombocytopenia and leukocytopenia, as well as changes in liver fibrosis markers and spleen size, in 115 patients with HCV-cirrhosis treated with DAAs.ResultsThrombocytopenia and leukocytopenia were improved 4 weeks after DAA administration, with thrombocytopenia show further gradual improvement over the next year. Fib-4 index was markedly reduced 1 year after DAA, followed by subsequent gradual reduction over the next 4 years. Spleen size showed gradual annual reductions, with patients experiencing spleen size reduction characterized at baseline by bilirubinemia.ConclusionsRapid DAA-associated HCV eradication might lead to rapid disappearance of liver inflammation and bone marrow suppression due to HCV infection. HCV eradication may gradually improve portal hypertension, reducing spleen size.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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