Inflammatory biomarkers in overweight and obese Iranian women are associated with polyphenol intake

Journal of Health, Population and Nutrition

Research

Farideh Shiraseb¹  Khadijeh Mirzaei²  Renata A. Carnauba³  Dorsa Hosseininasab⁴  Sahar Noori⁴  Rasool Ghaffarian-Ensaf⁴  Foad Asjodi⁵  Sara Ebrahimi⁶ 

[1] Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran;Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran;Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran;Department of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil;Food Research Center, CEPID-FAPESP (Research Innovation and Dissemination Centers, São Paulo Research Foundation), São Paulo, Brazil;Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran;IFMARK, FIFA Medical Center of Excellence, Tehran, Iran;The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Clayton, Melbourne, VIC, Australia;

关键词: Polyphenols;    Inflammation;    Obesity;    TGF-beta;    C-reactive protein;   

DOI  :  10.1186/s41043-023-00376-4

 received in 2023-01-23, accepted in 2023-04-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe evidence shows that obesity is associated with chronic inflammation in obese subjects. Polyphenols are a complex group of plant secondary metabolites that may play a role in reducing the risk of obesity and obesity-related diseases. Given the scarcity of evidence on the association between inflammatory markers and dietary polyphenols intake in overweight/obese Iranian women, the current study aims to investigate this link.MethodThe present cross-sectional study was conducted on 391 overweight and obese Iranian women aged 18–48 years (body mass index (BMI) ≥ 25 kg/m2). A 147-item food frequency questionnaire (FFQ) was used to assess dietary intake, as well as anthropometric indicesincluding weight, height, waist circumference (WC), and hip circumference (HC) and biochemistry parameters including triglyceride (TG), total cholesterol (Chole), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), serum glutamic pyruvic transaminase (SGPT), serum glutamic-oxaloacetic transaminase (SGOT), galactin-3 (Gal-3), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor beta (TGF-β), interleukin-1 beta (IL_1β), plasminogen activator inhibitor-1 (PA-I), serum leptin concentrations, and C-reactive protein of high sensitivity (hs-CRP) in all participants. The inflammatory markers were assessed using the enzyme-linked immunosorbent assay (ELISA).ResultThe findings revealed a significant negative association between flavonoids intake and MCP-1 (P = 0.024), lignans intake and MCP-1 (P = 0.017), and Gal-3 (P = 0.032). These significant associations were observed between other polyphenols intake and IL_1β (P = 0.014). There was also a significant positive association between other polyphenol intake and TGF-β (P = 0.008) and between phenolic acid intake and TGF-β (P = 0.014).ConclusionOur findings suggest that a high polyphenol intake may help individuals to reduce systemic inflammation. Further large studies involving participants of different ages and genders are highly warranted.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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