Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet

Lipids in Health and Disease

Fenghong Huang¹  Jin'e Yang¹  Qingde Huang¹  Qianchun Deng¹  Xiaoqi Zhou²  Jiqu Xu¹ 

[1]Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, P.R. China

[2]Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, P.R. China

关键词: Inflammation;    Plasma lipids;    Oxidant stress;    Atherosclerosis;    Phytosterols;    Tocopherols;    Polyphenols;    Rapeseed oil;   

Others  :  1212620
DOI  :  10.1186/1476-511X-10-96

 received in 2011-05-10, accepted in 2011-06-13,  发布年份 2011

【 摘 要 】

Background

Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to cardiovascular system, but most of these micronutrients are removed by the refining process. The aim of this study was to determine the effect of rapeseed oil fortified with these micronutrients on the atherosclerosis risk factors in rats fed a high-fat diet.

Methods

The rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified refined rapeseed oil with low, middle and high quantities of these micronutrients (L-, M- and H-FRRO). Forty male SD rats were divided into four groups. One group received RRO diet and other groups received L-, M- and H-FRRO diet for 10 weeks.

Results

Micronutrients supplementation significantly increased plasma antioxidant defense capacities, as evaluated by the significant elevation in the activities of GPx, CAT and SOD as well as the level of GSH, and the significant decline in lipid peroxidation. These micronutrients also reduced the plasma contents of TG, TC and LDL-C and increased the ratio of HDL-C/LDL-C. In addition, in parallel with the enhancement of these micronutrients, plasma levels of IL-6 and CRP declined remarkably.

Conclusion

Rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent atherogenesis by ameliorating plasma oxidative stress, lipid profile and inflammation.

【 授权许可】

   
2011 Xu et al; licensee BioMed Central Ltd.

【 图 表 】

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