Guillain–Barre syndrome after myocardial infarction: a case report and literature review

BMC Cardiovascular Disorders

Case Report

Chao Ren¹  Min Zhang¹  Hong-liang Wu¹  Wen-zheng Chu¹  Pu-yuan Wen²  Xian-wen Chen³ 

[1] Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000, Yantai, Shangdong, China;Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000, Yantai, Shangdong, China;Department of Neurology, The First Affiliated Hospital of Anhui Medical University, 230000, Hefei, Anhui, China;Department of Neurology, The First Affiliated Hospital of Anhui Medical University, 230000, Hefei, Anhui, China;

关键词: Guillain–Barre syndrome;    Myocardial infarction;    Immune-mediated response;    Surgery;    Streptokinase;   

DOI  :  10.1186/s12872-023-03261-4

 received in 2022-09-14, accepted in 2023-04-25,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundGuillain–Barre syndrome after myocardial infarction occurs infrequently, and its occurrence following percutaneous coronary intervention is extremely rare. Due to the high mortality rate of myocardial infarction and the disability of Guillain–Barre syndrome, early identification of Guillain–Barre syndrome after myocardial infarction and early intervention can decrease the mortality rate, lead to early recovery, and provide a better outcome.Case presentationHerein, we reported a rare case of Guillain–Barre syndrome after myocardial infarction treated with percutaneous coronary intervention. The patient was a 75-year-old woman from China who was admitted to hospital due to sudden loss of consciousness. Electrocardiography showed acute myocardial infarction in the right ventricle and inferior and posterior walls. The patient underwent emergency percutaneous intervention of the posterior collateral artery of the right coronary artery. Soon after, her condition worsened resulting in limb weakness and numbness. Unfortunately, she continued to develop respiratory failure, and treated with intravenous immunoglobulin and ventilator-assisted breathing. A physical examination showed hypotonia of all four limbs, complete quadriplegia, bulbar palsy, dysarthria, and tendon areflexia. Serum immunoglobulin (Ig) G anti-ganglioside antibody analysis was positive with anti-GT1a antibodies (+ +), anti-GM1 antibodies ( +), anti-GM2 antibodies ( +), and anti-GM4 antibodies ( +), and he was diagnosed with Guillain–Barre syndrome after myocardial infarction. She was discharged due to poor response to treatment. The patient died two days after being discharged.ConclusionsMyocardial infarction and/or percutaneous coronary intervention may activate immune-mediated response and cause severe complications. Clinician should be alert to Guillain–Barre syndrome after myocardial infarction and/or percutaneous coronary intervention.

【 授权许可】

CC BY   
© The Author(s) 2023. corrected publication 2023

【 图 表 】

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