Impact of psychosocial, behavioral and lifestyle factors on subjective cognitive complaints and perceived quality of life in a large cohort of Italian breast cancer patients

Frontiers in Psychology

article

Thomas West¹  Corrado Cavallero²  Rita Ceccherini³  Silva Foladore³  Daniele Generali⁴  Francesco Versace⁵  Bruna Scaggiante² 

[1] Lega Italiana per la Lotta contro i Tumori;Department of Life Sciences, University of Trieste;Breast Cancer Unit;Department of Medical, Surgery and Health Sciences, University of Trieste;The University of Texas MD Anderson Cancer Center

关键词: cancer-related cognitive impairment;    breast cancer;    Subjective Cognitive Complaints;    Adjuvant therapies;    chemotherapy;    Cognitive Reserve;    sleep quality;   

DOI  :  10.3389/fpsyg.2022.1015573

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The impact of psychosocial and behavioral factors on Cancer Related Cognitive Impairment manifestations is still under debate. The study aims to determine the prevalence rate of cancer-related cognitive impairment in a cohort of Italian breast cancer patients and to evaluate the implication of specific behavioral factors. For these purposes, a total of 233 women (106 breast cancer patients and 127 age-matched controls without oncological diagnosis) completed a questionnaire investigating cognitive functionality (FACT-Cog v3.0), sociodemographic characteristics, clinical information, psychosocial and behavioral factors (cognitive reserve, sleep quality, dietary habits, physical activity). The results indicated a higher prevalence rate of subjective cognitive complaints in breast cancer patients (37%) compared to a representative sample of women in the same age group without an oncological diagnosis (p<.001). Moreover, breast cancer patients showed significantly lower levels of cognitive reserve (p<.05) and worse sleep quality (p<.01) compared to age-matched controls. Further analysis revealed that breast cancer patients reporting subjective cognitive complaints differed significantly from breast cancer patients without subjective cognitive complaints on measures of perceived cognitive abilities (p<.001) and on the impact of cognitive difficulties on the perceived quality of life (p<.01). Future studies are needed to examine behavioral directed interventions to prevent subjective cognitive deficits in breast cancer patients.

【 授权许可】

CC BY