Cancer-related cognitive impairment in breast cancer survivors: an examination of conceptual and statistical cognitive domains using principal component analysis

Oncology Reviews

Barbara Collins¹  Angela Stewart²  Irene Vitoroulis²  Lea Ann Ouimet²  Catherine Bielajew²  Cynthia Wan²  Maude Lambert² 

[1] Ottawa Hospital, Civic Campus, Ottawa, Ontario;School of Psychology, University of Ottawa, Ontario;

关键词: Breast cancer survivors;    cancer-related cognitive impairment;    battery tests;    principal component analyses.;   

DOI  :  10.4081/oncol.2018.371

来源: DOAJ

【 摘 要 】

There is a great deal of variability in the composition of neuropsychological test batteries used in the assessment of cancer-related cognitive impairment (CRCI). Not only the development of a gold standard approach for CRCI assessment would allow for easier identification of women suffering from CRCI but it would also promote optimal care for survivors. As a first step towards the development of a valid and reliable unified test battery, the objective of this study was to verify whether the theoretical domains commonly used in CRCI assessment are statistically supported, before and after breast cancer treatment. Principal component analyses (PCA) were performed on the results from 23 neuropsychological tests grouped into eight conceptual domains. For baseline data, the Kaiser-Meyer-Olkin was .82 and Bartlett’s c2(253, N = 95) = 949.48, p < .001. A fivecomponent solution explained 60.94% of the common variance. For the post-treatment data, the Kaiser-Meyer-Olkin was .83 and Bartlett’s c2(253, N = 95) = 1007.21, p < .001 and a five component solution explained 62.03% of the common variance. Although a visual comparison of the theoretical model with those determined via PCA indicated important overlap between conceptual domains and statistical components, significant dissimilarities were also observed.

【 授权许可】

Unknown