Synthesis of 1-[4-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ylmethyl)-biphenyl-2-ylmethyl]-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid amide derivatives and evaluation of their platelet aggregation inhibition activity.

International Journal of ChemTech Research

article

Vasantha Mittapelli¹  Nageswar Rao Challa²  Venkateswara Rao Vallua³  Pratap Reddy Padi²  Mahesh Reddy Ghanta⁴ 

[1] Department of Chemistry, Mahatma Gandhi University;Process Research Laboratory, Research & Development Centre, Macleods Pharmaceuticals Ltd;Department of Chemistry, Pacific University;Process Research Laboratory, Brundavan Laboratories PVT Ltd

关键词: Antiplatetelet aggregation activity;    triazole;    thieno[3;    2-c]pyridine;    in vitro;    aggregometry;   

DOI  :  10.20902/IJCTR.2018.110218

学科分类：农业科学（综合）

来源: Sphinx Knowledge House

【 摘 要 】

In the present study, a new kind of 1-[4-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ylmethyl)-biphenyl-2-ylmethyl]-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid amidederivatives (6a-p) were synthesized. All newly synthesized compounds were characterized byIR, 1H NMR, 13C NMR and Mass spectra. The synthesized compounds were screened for theirAnti-Platelet Aggregation activity. All the compounds showed moderate to significantbiological activity compared with Clopidogrel bisulfate.

【 授权许可】

CC BY