Synthesis of Some New bis-(p-Fluorophenyl)amides of the Thieno[3,2-b]thiophene, Thieno[3,2-b]furan and 1,2-bis{5-[2-(2-Thienyl)ethenyl]2-thienyl}ethene Series

Molecules

Davorka Pavličić¹  Jasna Dogan Koružnjak¹  Zrinka Banić-Tomišić¹ 

[1] "Pliva" d.d., Research and Development, Prilaz baruna Filipovića 25, 10000 Zagreb, Croatia.

关键词: Amides;    thieno[3;    2-b]thienyl- series;    potential intercalators or groove binders;   

DOI  :  10.3390/71200871

来源: mdpi

【 摘 要 】

Three new heterocyclic substituted dianilides, namely 3-chloro-5-[1-(p-fluorophenylcarbamoyl)-2-(2-thienyl)ethenyl]thieno-[3,2-b]thiophene-2-carboxy-p-fluoro-anilide (8), 1,2-bis{5-[2-(p-fluorophenylcarbamoyl)-2-(2-thienyl)ethenyl]-2-thienyl}ethene (13) and 6-chloro-2-{2-[3-chloro-2-(p-fluorophenyl-carbamoyl)-5-thieno[3,2-b]thienyl]-2-ethoxycarbonylethenyl}thieno[3,2-b]furan-5-carboxy-p-fluoroanilide (20) were prepared by multistep synthesis. The prepared dianilides are of particular interest for their potential to serve as the planar heteroaromatic core of DNA intercalators or groove binders.

【 授权许可】

Unknown   
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