General Method for the Preparation of Substituted 2-Amino-4H,5H-pyrano[4,3-b]pyran-5-ones and 2-Amino-4H-pyrano[3,2-c]pyridine-5-ones

Molecules

关键词: pyrano[4;    3-b]pyran;    pyrano[3;    2-c]pyridine;    arylmethylene malononitrile;    arylmethylene cyanoacetate;    Michael addition;   

DOI  :  10.3390/50100019

来源: DOAJ

【 摘 要 】

Reaction of 4-hydroxy-6-methyl-2-pyrone (1a) as well as 4-hydroxy-6-methyl-2(1H)-pyridones (1b-d) with arylmethylene malononitriles or arylmethylene methyl cyanoacetates (2a-h) leads to the formation of the very stable 5,6-fused bicyclic 2-amino-4Hpyran derivatives 3a-3af.

【 授权许可】

Unknown