Symptomatic uncomplicated diverticular disease management: an innovative food-grade formulation of Curcuma longa and Boswellia serrata extracts

Drugs in Context

article

Attilio Giacosa¹  Antonella Riva³  Giovanna Petrangolini³  Pietro Allegrini³  Teresa Fazia⁴  Luisa Bernardinelli⁴  Clara Gasparri⁵  Milena Anna Faliva⁵  Gabriella Peroni⁵  Simone Perna⁶  Mariangela Rondanelli⁷ 

[1] Gastroenterology Unit, Policlinico di Monza;CDI;Research and Development Unit;Department of Brain and Behavioral Science, University of Pavia;Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia;Department of Biology, University of Bahrain, College of Science, Sakhir Campus P. O. Box;IRCCS Mondino Foundation;Department of Public Health, Experimental and Forensic Medicine, Unit of Human and Clinical Nutrition, University of Pavia

关键词: Boswellia;    curcumin;    dietary supplement;    food grade;    phytosome;    SUDD;   

DOI  :  10.7573/dic.2020-9-2

学科分类：社会科学、人文和艺术（综合）

来源: C S F Medical Communications Ltd.

【 摘 要 】

Background: The treatment of symptomatic uncomplicated colonic diverticular disease (SUDD) is still under debate, and new data show a pathogenic role of dysbiosis and low-grade inflammation in intestinal mucosa. Recent research has highlighted the anti-inflammatory effects of botanical extracts such as Curcuma longa L. and Boswellia serrata Roxb. ex Colebr. The aim of this work is to investigate the potential role of a new delivery formulation of the association of curcumin and boswellia phytosome extracts (CBP) in SUDD. Methods: In a 30-day one-group longitudinal explanatory study, patients (men and women) were treated with an innovative association of CBP standardized extracts, 500 mg bid. Results: Treatment of SUDD with the association of CBP was followed by a significant decrease in abdominal pain (p<0.0001). The study group showed that CBP supplementation was efficacious within 10 days and that efficacy was maintained almost constant until the 30th day of intervention. Conclusion: A phytosome of curcumin and boswellia extracts may be useful for the relief of SUDD pain. However, controlled studies should be performed for final conclusions to be drawn.

【 授权许可】

CC BY-NC-ND