A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps

International Journal of Molecular Sciences

Matteo Puntoni¹  Silvia Caviglia²  Matteo Lazzeroni³  Paola Romagnoli⁴  Massimo Oppezzi⁴  Mauro Dalla Libera⁴  Marilena Petrera⁵  Irene Maria Briata⁵  Andrea DeCensi⁵  Giacomo Siri⁶  Mariangela Rutigliani⁶  Raj Singh⁷  Lynne Howells⁷  Karen Brown⁷  Laura Paleari⁸ 

[1] Clinical & Epidemiological Research Unit, University Hospital of Parma, 43126 Parma, Italy;Clinical Trial Unit, Office of the Scientific Director, E.O. Galliera Hospital, 16128 Genoa, Italy;Division of Cancer Prevention and Genetics, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy;Division of Gastroenterology, E.O. Galliera Hospital, 16128 Genoa, Italy;Division of Medical Oncology, E.O. Galliera Hospital, 16128 Genoa, Italy;Division of Pathology, E.O. Galliera Hospital, 16128 Genoa, Italy;Leicester Cancer Research Centre, University of Leicester, Leicester LE1 7RH, UK;Research, Innovation and HTA, A.Li.Sa. Liguria Health Authority, 16121 Genoa, Italy;

关键词: curcumin;    anthocyanins;    adenomatous polyps;    dietary supplement;    Ki-67 antigen;    NF-kappa B;   

DOI  :  10.3390/ijms222011024

来源: DOAJ

【 摘 要 】

Adenomatous polyps are precancerous lesions associated with a higher risk of colorectal cancer (CRC). Curcumin and anthocyanins have shown promising CRC-preventive activity in preclinical and epidemiological studies. The objective of this window-of-opportunity, proof-of principle trial was to evaluate the effect of curcumin combined with anthocyanin supplements on tissue biomarkers of colorectal adenomatous polyps. Eligible patients received either anthocyanin and curcumin supplementation or related matching placebo for 4–6 weeks before polyp removal. Adenomatous polyps and adjacent tissue biopsies were collected at baseline and after supplementation for immunohistochemical assessment of β-catenin, NF-kappa B (NF-κB), Ki-67, P53, and dysplasia. No differences were observed in baseline biomarker expression between normal and dysplastic tissues. The combination of anthocyanins and curcumin resulted in a significant borderline reduction of NF-κB immunohistochemistry (IHC) expression in adenoma tissue (geometric mean ratio (GMR): 0.72; 95% confidence interval (CI): 0.51–1.00; p-value: 0.05) and a trend to a reduction of Ki-67 (GMR: 0.73; 95% CI: 0.50–1.08; p-value: 0.11). No significant modulation of biomarkers in normal adjacent mucosa was observed. We concluded that the combined supplementation of anthocyanins and curcumin seems to lead to a potentially favorable modulation of tissue biomarkers of inflammation and proliferation in colon adenomas.

【 授权许可】

Unknown