Using Unconditional Logistic Regression to Assess Prostate Cancer Risk Factors: Practical Messages for Public Health

Journal of Data Science

article

Rasool Roozegar¹  Alireza Khoshdel² 

[1] Department of Statistics, Yazd University;Department of Epidemiology, Aja University of Medical Sciences

关键词: Unconditional logistic regression;    Prostate cancer;    Risk factors;    age;    smoking;    family history;   

DOI  :  10.6339/JDS.201607_14(3).0003

学科分类：土木及结构工程学

来源: JDS

【 摘 要 】

Objectives: Risk assessment, early diagnosis and timely treatment ofprostate cancer have a great role in survival and quality of life of patients. Assuminga different cancer epidemiology in developing countries, this study aimed toidentify risk factors for prostate cancer in southern Iran to be implicated in Asiandeveloping countries' public health systems.Methods: A case-control study of prostate cancer (PCa) was undertaken in twoIranian provinces. Ninety eight Cases with histologically confirmed incidentdisease and 98 control patients treated in the same hospitals for other minor diseases(2005-2010) were included. The data about demographic, socio-economic, sexualand biomedical variables were modeled through unconditional Logistic regression(using the EGRET and SPSS) as well as odds ratios and 95% confidence intervals.Results: There was no significant difference between the groups in terms ofanthropometric variables (including height and BMI), marital, birth order ofchildren, sexual function, history of STD and testosterone related phenotypebetween the two groups. However urban residency, smoking, patient's age andfamily history of prostate cancer were determined as significant risk factors for PCa(P= 0.006, P=0.03, P=0.008 and P=0.006, respectively). Among the reported pastdisease history, only the history of TB disease was a significant determinant(OR=2.08, P=0.01).Conclusion: The results are evidence against a relationship between anthropometricmeasures, marital status, sexual behavior, alcohol consumption and past medicalhistory (including history of STD) and in favor of a relationship of age, familyhistory of prostate cancer, urban residency and smoking with prostate cancer.

【 授权许可】

CC BY