A case control study investigating the effects of levels of physical activity at work as a risk factor for prostate cancer

Environmental Health

Research

Gianluca Severi¹  Geza Benke²  Graham G Giles³  Glenn W Doolan⁴  Timo Kauppinen⁵ 

[1] Cancer Epidemiology Centre, Cancer Council Victoria, 615 St. Kilda Road, 3004, Melbourne, Victoria, Australia;Centre for Genetic Epidemiology, University of Melbourne, 200 Berkeley Street, 3053, Carlton, Victoria, Australia;Department of Epidemiology & Preventive Medicine, Monash University, The Alfred Centre, The Alfred, Commercial Road, 3004, Melbourne, Victoria, Australia;Department of Epidemiology & Preventive Medicine, Monash University, The Alfred Centre, The Alfred, Commercial Road, 3004, Melbourne, Victoria, Australia;Cancer Epidemiology Centre, Cancer Council Victoria, 615 St. Kilda Road, 3004, Melbourne, Victoria, Australia;Centre for Genetic Epidemiology, University of Melbourne, 200 Berkeley Street, 3053, Carlton, Victoria, Australia;Department of Epidemiology & Preventive Medicine, Monash University, The Alfred Centre, The Alfred, Commercial Road, 3004, Melbourne, Victoria, Australia;P.O. Box 276, 3824, Trafalgar, Victoria, Australia;Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, 00250, FIN, Helsinki, Finland;

关键词: Manual handling of burdens;    Occupational exposure;    Physical activity;    Physical workloads;    Prostate cancer;    Risk factors;    Finish job exposure matrix;   

DOI  :  10.1186/1476-069X-13-64

 received in 2014-01-14, accepted in 2014-07-25,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundA potential risk factor for prostate cancer is occupational physical activity. The occupational aetiology of prostate cancer remains unclear. The purpose of this research was to examine associations between the level of exposure to various measures of physical activity at work and the risk of Prostate Cancer.MethodsUsing the Finnish Job Exposure Matrix and the occupational history of 1,436 cases and 1,349 matched controls from an Australian case control study; we investigated five related exposure variables considered to be risk factors by comparing odds ratios.ResultsModestly increasing odds ratios were detected with increasing levels of workload but there was no difference in this trend between moderate and high grade tumours. In regard to occupational physical workload no statistically significant association was observed overall but an increasing trend with level of exposure was observed for high grade compared with moderate grade tumours.ConclusionBoth workload and physical workload merit further investigation, particularly for the latter in relation to grade of tumour.

【 授权许可】

CC BY   
© Doolan et al.; licensee BioMed Central Ltd. 2014