Knowledge gaps and research priorities in tuberculous meningitis

Wellcome Open Research

article

James A Seddon¹  Robert Wilkinson¹  Reinout van Crevel⁶  Anthony Figaji⁸  Guy E Thwaites⁷ 

[1] Infectious Diseases, Imperial College London;Paediatric Infectious Diseases, Imperial College Healthcare NHS Trust, St. Mary's Campus;Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University;Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town;Francis Crick Institute;Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Centre;Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford;Neuroscience Institute, Division of Neurosurgery, University of Cape Town;Oxford University Clinical Research Unit, University of Oxford

关键词: Tuberculosis;    Tuberculous Meningitis;    Research Priorities;    Epidemiology;    Diagnosis;    Treatment;    Critical Care;    Care Cascade;   

DOI  :  10.12688/wellcomeopenres.15573.1

学科分类：内科医学

来源: Wellcome

【 摘 要 】

Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), accounting for around 1-5% of the global TB caseload, with mortality of approximately 20% in children and up to 60% in persons co-infected with human immunodeficiency virus even in those treated. Relatively few centres of excellence in TBM research exist and the field would therefore benefit from greater co-ordination, advocacy, collaboration and early data sharing. To this end, in 2009, 2015 and 2019 we convened the TBM International Research Consortium, bringing together approximately 50 researchers from five continents. The most recent meeting took place on 1st and 2nd March 2019 in Lucknow, India. During the meeting, researchers and clinicians presented updates in their areas of expertise, and additionally presented on the knowledge gaps and research priorities in that field. Discussion during the meeting was followed by the development, by a core writing group, of a synthesis of knowledge gaps and research priorities within seven domains, namely epidemiology, pathogenesis, diagnosis, antimicrobial therapy, host-directed therapy, critical care and implementation science. These were circulated to the whole consortium for written input and feedback. Further cycles of discussion between the writing group took place to arrive at a consensus series of priorities. This article summarises the consensus reached by the consortium concerning the unmet needs and priorities for future research for this neglected and often fatal disease.

【 授权许可】

CC BY