The Effect of Transurethral Resection and BCG Therapy on Cytokine Levels in Non-Muscle Invasive Bladder Cancer

Journal of Urological Surgery

article

Oktay Üçer¹  Gökhan Temeltaş¹  Talha Müezzinoğlu¹  Zeki Ari²  Funda Kosova³ 

[1] Manisa Celal Bayar University Faculty of Medicine, Department of Urology;Manisa Celal Bayar University Faculty of Medicine, Department of Medical Biochemistry;Manisa Celal Bayar University School of Health Science

关键词: Bladder cancer;    IL-1;    IL-6;    IL-8;    neopterin;   

DOI  :  10.4274/jus.galenos.2022.2021.0099

学科分类：社会科学、人文和艺术（综合）

来源: Galenos Yayinevi

【 摘 要 】

Objective: The present study investigated the effect of treatment on interleukin (IL)-1, IL-6, IL-8, and neopterin levels in patients with non-muscle invasive bladder cancer (NMIBC). Materials and Methods: Thirty patients with NMIBC and 30 age-matched controls were included in the study. Preoperative, postoperative first control [at two weeks after second transurethral resection of bladder tumor (TURBT)] and the second control (at the end of intravesical immunotherapy) blood samples were analyzed using ELISA to determine IL-1, IL-6, IL-8, and neopterin levels. The mean cytokine levels of the patients were statistically compared and comparing the patients’ and controls’ levels. Results: There were no statistically significant differences between the mean IL-1, IL-6, IL-8, and neopterin levels of the patient and control groups before initial TURBT. In the patient group, there were no statistically significant differences in the IL-6 and IL-8 levels after both TURBT and intravesical Bacillus Calmette-Guérin (BCG) therapy. The mean of preoperative IL-1 and neopterin levels significantly decreased after TURBT (p<0.05). However, this reduction does not continue after intravesical BCG instillation. Conclusion: The findings of this study showed that the IL-1, IL-6, IL-8, and neopterin levels of the patients with NMIBC were similar to the levels of healthy controls. IL-1 and neopterin levels significantly decreased after TURBT. But these reduction did not continue after intravesical BCG instillation. These findings demonstrate that IL-1 and neopterin levels decrease after TURBT due to the reduction in tumor weight or tumor removal.

【 授权许可】

CC BY-NC-ND