Allogeneic Mesenchymal Stem Cells and Its Conditioned Medium as a Potential Adjuvant Therapy for COVID-19

Molecular and Cellular Biomedical Sciences: MCBS

article

Wahyu Widowati¹  Ahmad Faried²  Hanna Sari Widya Kusuma³  Yulius Hermanto²  Ali Budi Harsono⁴  Tono Djuwantono⁴ 

[1] Faculty of Medicine, Maranatha Christian University;Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin Hospital;Biomolecular and Biomedical Research Center;Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin Hospital

关键词: adjuvant therapy;    COVID-19;    mesenchymal stem cells;    secretome;   

DOI  :  10.21705/mcbs.v7i1.287

来源: Cell and BioPharmaceutical Institute

【 摘 要 】

Recent research has demonstrated that mesenchymal stem cells (MSCs) potentially benefit and enhance coronavirus disease (COVID-19) recovery. This benefit occurs via a mechanism that promotes viral clearance by phagocytes and macrophages. This action occurs through the innate (increase in IL-10 production and decrease in TNF-α and IL-12 production) and the adaptive immune system (decrease in IL-17 production, promote regulatory T cell proliferation and inhibit effectors T cell proliferation). MSCs are expected to act as an anti-inflammatory in the hyper-inflammatory state of COVID-19. MSCs enhance immune cell replacement that have been overwhelmed or have been lost due to cytokine storm. Although vaccines are the answer to this pandemic, MSCs can improve COVID-19 patients, especially in patients with chronic illnesses. The focus on keeping death-rates low is a great opportunity for MSCs-based therapy for severe or critically ill patients. MSCs and conditioned medium have the potential to serve as adjunctive therapy in preventing the body's overactive defense response or the so-called cytokine storm caused by COVID-19.

【 授权许可】

Unknown