Mesenchymal Stem Cell Secretome as an Emerging Cell-Free Alternative for Improving Wound Repair

International Journal of Molecular Sciences

Parinaz Ahangar¹  AllisonJ. Cowin¹  StuartJ. Mills¹ 

[1] Future Industries Institute, University of South Australia, Adelaide, SA 5000, Australia;

关键词: mesenchymal stem cells;    secretome;    wound healing;   

DOI  :  10.3390/ijms21197038

来源: DOAJ

【 摘 要 】

The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is currently of enormous interest. However, the broad translation of cell therapies into clinical use is hampered by their efficacy, safety, manufacturing and cost. MSCs release a broad repertoire of trophic factors and immunomodulatory cytokines, referred to as the MSC secretome, that has considerable potential for the treatment of cutaneous wounds as a cell-free therapy. In this review, we outline the current status of MSCs as a treatment for cutaneous wounds and introduce the potential of the MSC secretome as a cell-free alternative for wound repair. We discuss the challenges and provide insights and perspectives for the future development of the MSC secretome as well as identify its potential clinical translation into a therapeutic treatment.

【 授权许可】

Unknown