Hydrogel Encapsulation: Taking the Therapy of Mesenchymal Stem Cells and Their Derived Secretome to the Next Level

Frontiers in Bioengineering and Biotechnology

Lina Yang¹  Yuling Huang¹  Xin Li² 

[1] Departments of Geriatrics, First Affiliated Hospital of China Medical University, Shenyang, China;Departments of Infectious Disease, First Affiliated Hospital of China Medical University, Shenyang, China;

关键词: hydrogel;    extracellular vesicles;    biomaterials;    secretome;    mesenchymal stem cells;   

DOI  :  10.3389/fbioe.2022.859927

来源: DOAJ

【 摘 要 】

Biomaterials have long been the focus of research and hydrogels are representatives thereof. Hydrogels have attracted much attention in the medical sciences, especially as a candidate drug-carrier. Mesenchymal stem cells (MSC) and MSC-derived secretome are a promising therapeutic method, owing to the intrinsic therapeutic properties thereof. The low cell retention and poor survival rate of MSCs make further research difficult, which is a problem that hydrogel encapsulation largely solved. In this review, safety and feasibility of hydrogel-encapsulated MSCs, the improvement of the survival, retention, and targeting, and the enhancement of their therapeutic effect by hydrogels were studied. The status of the hydrogel-encapsulated MSC secretome was also discussed.

【 授权许可】

Unknown