EK-16A liposomes enhance HIV replication in ACH2 or J-Lat 10.6 cell engrafted NSG mice

Nanotheranostics

article

Panpan Lu¹  Jinlong Yang¹  Xinyi Yang¹  Zhiming Liang¹  Jing Wang¹  Yanan Wang¹  Lin Zhao¹  Hanyu Pan¹  Xiaoting Shen¹  Yuqi Zhu¹  Jingna Xun¹  Hongzhou Lu²  Huanzhang Zhu¹ 

[1] State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Fudan University;Department of Infectious Disease, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University

关键词: HIV;    LRAs;    Euphorbia kansui;    EK-16A;    NSG mouse model;   

DOI  :  10.7150/ntno.69259

学科分类：大气科学

来源: Ivyspring International Publisher

【 摘 要 】

Background: Numbers of HIV latency reversal agents (LRAs) have been tested in clinical trials, but with limited effect. EK-16A is an ingenol derivative that isolated from Euphorbia kansui. Our prior studies have suggested that it could reactivate latent HIV and meanwhile inhibit HIV infection in vitro. Here, we further advanced the research in vivo.

【 授权许可】

CC BY-NC