Prevalence of methicillin-resistant Staphylococcus aureus colonization in HIV-infected patients in Barcelona, Spain: a cross-sectional study

BMC Infectious Diseases

Daniel Podzamczer⁴  Miquel Pujol¹  Margarita Maso-Serra⁴  Antonia Vila⁴  M Angeles Dominguez³  Oriol Gasch²  Silvana Di Yacovo⁴  Mariana Camoez³  Arkaitz Imaz⁴ 

[1] Infectious Diseases Department, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain;Infectious Diseases Department, Corporació Sanitària Parc Taulí, Sabadell, Spain;Microbiology Department, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain;HIV Unit, Infectious Diseases Department, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain

关键词: Colonization;    Methicillin-resistant Staphylococcus aureus;    HIV;   

Others  :  1230334
DOI  :  10.1186/s12879-015-0991-z

 received in 2015-02-01, accepted in 2015-06-19,  发布年份 2015

【 摘 要 】

Background

Colonization by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been found to be markedly more common in HIV-infected individuals in the USA. Studies evaluating the prevalence MRSA colonization in HIV-infected populations in Europe are scarce. The aim of this study was to investigate the prevalence of MRSA colonization in a cohort of HIV-infected patients in Barcelona, Spain.

Methods

Nasal and pharyngeal S. aureus carriage was assessed in a random sample of 190 patients from an outpatient HIV clinic. Nasal and pharyngeal swab specimens were obtained for staphylococcal culture from 190 and 110 patients respectively. All MRSA isolates were screened for Panton-Valentine leukocidin (PVL) genes by PCR. Molecular characterization of MRSA isolates was performed by multilocus sequence typing. Data related to HIV infection, healthcare exposure, and previously described risk factors for MRSA were collected from medical records and a questionnaire administered to each patient.

Results

The patients’ characteristics were as follows: male, 83 %; median (IQR) age, 45 (39–49) years; intravenous drug users, 39 %; men who have sex with men, 32 %; heterosexual, 26 %; CD4 count, 528/μL (IQR 351–740); on antiretroviral therapy, 96 %; and undetectable plasma viral load, 80 %. Sixty-five patients (34 %) were colonized by S. aureus. MRSA colonization was found in 1 % and 2 % of nasal and pharyngeal samples respectively. No PVL positive MRSA strains were detected and all the MRSA isolates belonged to typical hospital-acquired clones.

Conclusions

Our data suggest that CA-MRSA colonization is not currently a problem in HIV-infected individuals in our area.

【 授权许可】

   
2015 Imaz et al.

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