A cross sectional study of animal and human colonization with Methicillin-Resistant Staphylococcus aureus (MRSA) in an Aboriginal community

BMC Public Health

Research Article

Carla Penney¹  Janak Bajgai²  Peter Daley³  Hugh Whitney⁴  Scott Weese⁵  Karen Williams⁶  George R. Golding⁷ 

[1] Department of Clinical Epidemiology, Memorial University, St. John’s, Canada;Department of Community Health, Memorial University, St. John’s, Canada;Department of Medicine and Laboratory Medicine, Memorial University, Room 1 J421 300 Prince Phillip Dr, A1B 3V6, St. John’s, Newfoundland and Labrador, Canada;Department of Public Health, Government of Newfoundland and Labrador, St. John’s, Canada;Department of Veterinary Medicine, University of Guelph, Guelph, Canada;Happy Valley Goose Bay, Labrador, Canada;National Microbiology Laboratory, Winnipeg, Canada;

关键词: Methicillin-resistant Staphylococcus aureus;    Aboriginal;    Dog;    Colonization;   

DOI  :  10.1186/s12889-016-3220-9

 received in 2015-12-19, accepted in 2016-06-08,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) infections are common among humans in Aboriginal communities in Canada, for unknown reasons.MethodsCross sectional study of humans and dogs in an Aboriginal community of approximately 1200 persons. Our objectives were to measure community-based prevalence of nasal MRSA colonization among humans, use multivariable logistic regression to analyze risk factors for MRSA colonization, and perform molecular typing of Staphylococci isolated to investigate interspecies transmission.Results461 humans were approached for consent and 442 provided complete data. 109/442 (24.7 %, 95 % C.I. = 20.7–28.7 %) of humans were colonized with MRSA. 169/442 (38.2 %) of humans had received antibiotics in the last 12 months. Only number of rooms in the house (OR 0.86, p = 0.023) and recreational dog use (OR 7.7, p = 0.002) were significant risk factors for MRSA colonization. 95/109 (87.1 %) of MRSA strains from humans were of the same spa type (CMRSA10/USA300). 8/157 (5.1 %, 95 % C.I. = 1.7–8.5 %) of dogs were colonized with methicillin-susceptible S. aureus, and no dogs were colonized with MRSA.ConclusionsHuman MRSA colonization in this community is very common, and a single clone is predominant, suggesting local transmission. Antibiotic use is also very common. Crowding may partially explain high colonization, but most considered risk factors including animal exposure were not predictive. Very few dogs carried human Staphylococcal strains.

【 授权许可】

CC BY   
© The Author(s). 2016