Review on Optical Imaging Techniques for Multispectral Analysis of Nanomaterials

Nanotheranostics

article

Haeni Lee¹  Jaeheung Kim¹  Hyung-Hoi Kim²  Chang-Seok Kim¹  Jeesu Kim¹ 

[1] Department of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University;Department of Laboratory Medicine and Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine

关键词: Multispectral imaging;    Nanoparticles;    Spectral unmixing;    Contrast-enhanced imaging;    Biomedical imaging;   

DOI  :  10.7150/ntno.63222

学科分类：大气科学

来源: Ivyspring International Publisher

【 摘 要 】

Biomedical imaging is an essential tool for investigating biological responses in vivo. Among the several imaging techniques, optical imaging systems with multispectral analysis of nanoparticles have been widely investigated due to their ability to distinguish the substances in biological tissues in vivo. This review article focus on multispectral optical imaging techniques that can provide molecular functional information. We summarize the basic principle of the spectral unmixing technique that enables the delineation of optical chromophores. Then, we explore the principle, typical system configuration, and biomedical applications of the representative optical imaging techniques, which are fluorescence imaging, two-photon microscopy, and photoacoustic imaging. The results in the recent studies show the great potential of the multispectral analysis techniques for monitoring responses of biological systems in vivo.

【 授权许可】

CC BY-NC