Anabolic and antiresorptive actions of locally delivered bisphosphonates for bone repair: A review

Bone & Joint Research

article

I. Qayoom¹  D. B. Raina²  A. Širka³  Š. Tarasevičius³  M. Tägil²  A. Kumar⁴  L. Lidgren² 

[1] Department of Biological Sciences and Bioengineering, Indian Institute of Technology;Department of Orthopedics, The Medical Faculty, Clinical Sciences Lund, Lund University;Department of Orthopedics and Traumatology, Lithuanian University of Health Sciences;Department of Biological Sciences and Bioengineering, Centre for Environmental Sciences and Engineering, Centre for Nanosciences, Indian Institute of Technology Kanpur

关键词: Bisphosphonates;    Bone repair;    Ceramic;    Local delivery;    Zoledronic acid;    Carrier;   

DOI  :  10.1302/2046-3758.710.BJR-2018-0015.R2

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

During the last decades, several research groups have used bisphosphonates for local application to counteract secondary bone resorption after bone grafting, to improve implant fixation or to control bone resorption caused by bone morphogenetic proteins (BMPs). We focused on zoledronate (a bisphosphonate) due to its greater antiresorptive potential over other bisphosphonates. Recently, it has become obvious that the carrier is of importance to modulate the concentration and elution profile of the zoledronic acid locally. Incorporating one fifth of the recommended systemic dose of zoledronate with different apatite matrices and types of bone defects has been shown to enhance bone regeneration significantly in vivo. We expect the local delivery of zoledronate to overcome the limitations and side effects associated with systemic usage; however, we need to know more about the bioavailability and the biological effects. The local use of BMP-2 and zoledronate as a combination has a proven additional effect on bone regeneration. This review focuses primarily on the local use of zoledronate alone, or in combination with bone anabolic factors, in various preclinical models mimicking different orthopaedic conditions.

【 授权许可】

CC BY-NC