Journal of Nanobiotechnology | |
Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy | |
Ruiying Chen1  Xiaomeng Zhang1  Hongchang Lai1  Junyu Shi1  Jianxu Wei1  Yi Zhang2  Jiazhen Hou3  Bing Wang3  Yongzhuo Huang4  | |
[1] Department of Implant Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineCollege of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, 200011, Shanghai, China;Department of Implant Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineCollege of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, 200011, Shanghai, China;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Rd, 201203, Shanghai, China;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Rd, 201203, Shanghai, China;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Rd, 201203, Shanghai, China;Zhongshan Institute for Drug Discovery, SIMM, CAS, 528437, Zhongshan, China;NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, 201203, Shanghai, China;Taizhou University, School of Advanced Study, Institute of Natural Medicine and Health Product, 318000, Taizhou, China; | |
关键词: Resveratrol; Macrophage; Periodontitis; Liposome; Immune microenvironment; Local delivery; | |
DOI : 10.1186/s12951-021-01175-x | |
来源: Springer | |
【 摘 要 】
BackgroundPeriodontitis is a complicated inflammatory disease that damages the tooth-supporting tissues, with limited pharmacotherapy available. Macrophage-targeting therapy is promising for inflammatory diseases. Resveratrol (RSV), a nonflavonoid polyphenol, is known for its anti-inflammatory and immunomodulatory effects. However, its medical application is limited by its poor stability and water-solubility, as well as its low bioavailability.ResultA therapeutic resveratrol-loaded liposomal system (Lipo-RSV) was developed to treat periodontitis. The physical properties of Lipo-RSV and its ability to regulate macrophages were investigated. The results showed that Lipo-RSV had good biocompatibility and could re-educate the inflammatory macrophages from M1- to M2-like phenotype through activating p-STAT3 and downregulating p-STAT1. Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-κB signal and inflammasomes, thereby reducing the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α.ConclusionThese results revealed that Lipo-RSV could be a potential therapeutic system for the antibiotic-free treatment for periodontal diseases.Graphical Abstract
【 授权许可】
CC BY
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