Comparative analysis of prophage-like elements in Helicobacter sp. genomes

PeerJ

article

Xiangyu Fan¹  Yumei Li¹  Rong He¹  Qiang Li¹  Wenxing He¹ 

[1] School of Biological Science and Technology, University of Jinan

关键词: Helicobacter;    Prophage;    Phylogeny;    Comparative genomics;   

DOI  :  10.7717/peerj.2012

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Prophages are regarded as one of the factors underlying bacterial virulence, genomic diversification, and fitness, and are ubiquitous in bacterial genomes. Information on Helicobacter sp. prophages remains scarce. In this study, sixteen prophages were identified and analyzed in detail. Eight of them are described for the first time. Based on a comparative genomic analysis, these sixteen prophages can be classified into four different clusters. Phylogenetic relationships of Cluster A Helicobacter prophages were investigated. Furthermore, genomes of Helicobacter prophages from Clusters B, C, and D were analyzed. Interestingly, some putative antibiotic resistance proteins and virulence factors were associated with Helicobacter prophages.

【 授权许可】

CC BY